A CAAT Timeline: 1981-2002

1981

CAAT established with $1 million grant from Cosmetic, Toiletry, and Fragrance Association (CTFA).
Geraldine R. Dodge Foundation supports publication of CAAT Newsletter.

1982

First CAAT Symposium: "Product Safety Evaluation: Development of New Methodological Approaches."
CAAT funds first 16 grants.

1983

1984

1985

CAAT In Vitro Toxicology Laboratory established.
Bausch & Lomb, Inc., awards CAAT funds to conduct and publish critical review of Draize eye test and potential alternatives.

1986

Fourth CAAT Symposium: "In Vitro Toxicology: Approaches to Validation."
CAAT/Bausch & Lomb, Inc., sponsor workshop on "A Critical Evaluation of Alternatives to Acute Ocular Irritation Testing."

1987

1988

Avon Products, Inc. funds first Program Project (alternatives to animal use in contact allergy testing).

1989

First meeting of CAAT Subcommittee on Validation and Technology Transfer.
Sixth CAAT Symposium: "In Vitro Toxicology: New Directions."
NIH/NIEHS becomes first federal agency to fund CAAT.
CAAT holds first technical workshop, on "Technical Problems with In Vitro Toxicity Testing Systems."
First meeting of CAAT Government Exchange Group.

1990

CAAT/European Research Group for Alternatives in Toxicity Testing (ERGATT) sponsor workshop on validation.
CAAT/Ciba-Geigy sponsor technical workshop on "Structure-Activity Relationships in Predictive Toxicology."
First CAAT/Tissue Culture Association (TCA) workshop: "Cell Culture and In Vitro Toxicity Tests."
Seventh CAAT Symposium: "In Vitro Toxicology: Mechanisms and New Technology."

1991

Second CAAT/TCA Workshop: "The International Status of Validation of In Vitro Toxicology Tests."
Goldberg presented with Russell and Burch Award by the Humane Society of the United States.

1992

The Environmental Protection Agency (EPA) funds Program Project in in vitro neurotoxicology.
CAAT launches In Vitro Toxicology Program at Johns Hopkins School of Public Health.

1993

CAAT holds technical workshop on "Molecular and Cellular Approaches to Extrapolation for Risk Assessment."
CAAT organizes "First World Congress on Alternatives and Animal Use in the Life Sciences" in Baltimore.

1994

Animals and Alternatives in Testing: History, Science, and Ethics, CAAT's first book on the alternatives field for the general public, is published.
CAAT publishes first issue of CAATalyst, a publication created to educate middle school students about alternatives.
Eighth CAAT Symposium: "In Vitro Approaches to Contact Dermatitis."

1996

Second World Congress on Alternatives meets in The Netherlands.
CAAT is asked by a consortium of industry, government, and animal protection organizations to create a website devoted to alternatives; Procter & Gamble becomes first sponsor of Altweb, the Alternatives to Animal Testing Website.

1997

CAAT, National Institutes of Health (NIH) sponsor workshop on "Alternatives in Monoclonal Antibody Production." (NIH issues "Dear Colleague" letter following workshop, asking IACUCs to consider in vitro methods first.)
Altweb is launched.
CAAT asks Animal Welfare Information Center (AWIC) to prepare database on analgesia and anesthesia for Altweb.

1998

CAAT introduces TestSmart Program.
CAAT, NIH, and Institute for Laboratory Animal Research (ILAR) sponsor workshop on "Pain Management and Humane Endpoints."

1999

First major TestSmart workshop convened. (EPA announces 80% decrease in estimated number of animals needed for HPV tests.)
Third World Congress on Alternatives meets in Bologna, Italy.
CAAT receives funding from NIH to develop global search engine for Altweb.

2000

CAAT launches search engine capable of searching multiple websites simultaneously.
CAAT creates new website about its own programs and agrees to develop, manage website for the triennial World Congress.
CAAT establishes &CAAT faculty& to promote the 3Rs at Johns Hopkins and elsewhere.
Special section on monoclonal antibodies created for Altweb.

2001

Major TestSmart workshop on pharmaceuticals convened in Baltimore.
Pain management database completed and made available on Altweb.
CAAT celebrates 20 years of humane science at 20^th anniversary symposium.
CAAT launches new Refinement Program Project; Paul Flecknell presents first lecture.
CAAT establishes Genomics Laboratory at the Bloomberg School of Public Health.
CAAT Advisory Board members issue statement in support of the inclusion of rats, mice,and birds in the Animal Welfare Act.
Goldberg receives Doerenkamp-Zbinden Award (along with Ian Kimber) and the Society of Toxicology's Enhancement of Animal Welfare Award

2002

Major TestSmart workshop on endocrine disruptors convened in Fairfax, Va.
Goldberg completes Dutch course on Laboratory Animal Science.
Goldberg invited to make a presentation on alternatives before the British House of Lords.
Alicia Karas presents second lecture in the Refinement Program Project series: "Perspectives On Postoperative Pain In The Laboratory Mouse."
Fourth World Congress on Alternatives meets in New Orleans.
Linda Toth presents the third lecture in the Refinement Program Project series: "Refining Animal Use in Research Models: Integrating Scientific Goals and Animal Care."