The Center for Alternatives to Animal Testing is an academic center affiliated with the Division of Toxicological Sciences in the Department of Environmental Health Sciences of the Johns Hopkins University Bloomberg School of Public Health.

 

Johns Hopkins School of Public Health

Research Grants 1984-1985

Surface Topography and Tight Junctions Integrity in Epithelial and Endothelial Cell Lines

Michael Edidin, PhD
Johns Hopkins University, Baltimore, Maryland

Michael Edidin, PhD, professor of biology at the Johns Hopkins University, has developed skin cell cultures to detect early biological changes associated with toxicity. He labels these cells with fluorescent dye to track the movement of fat and protein molecules in cell membranes. Changes in the rate of movement indicate membrane damage, one of the first signs of toxicity.

These scientists and others will present a complete report on the first two years of CAAT-funded research at the CAAT symposium in October.