The Center for Alternatives to Animal Testing is an academic center affiliated with the Division of Toxicological Sciences in the Department of Environmental Health Sciences of the Johns Hopkins University Bloomberg School of Public Health.
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Research Grants 1986-1987
Use of Isolated Rabbit Renal Tubules for the Detection and Investigation of Nephrotoxins
A. Jay Gandolfi, PhD
University of Arizona College of Medicine, Tucson, Arizona
Gandolfi has used CAAT funding to develop two in vitro methods for studying kidney toxicity, one using slices of rabbit kidney and the other using rabbit kidney tubules, minute structures important in the maintenance of proper blood chemistry. With these two cultures, Gandolfi will study the mechanisms of kidney toxicity and develop a pair of alternative tests that can identify drugs with both direct and indirect toxic effects on the kidney.