The Center for Alternatives to Animal Testing is an academic center affiliated with the Division of Toxicological Sciences in the Department of Environmental Health Sciences of the Johns Hopkins University Bloomberg School of Public Health.
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Research Grants 1986-1987
Primary Cultures of Renal Proximal Tubules: A New In Vitro Model for Assessing Drug and Chemical Induced Nephrotoxicity
Paul J. Kostyniak, PhD, Mary L. Taub, PhD, and James R. Olson, PhD
State University of New York Faculty of Health Sciences, Buffalo, New York
Kostyniak and his associates will use cultures of rabbit kidney tubules to study the cellular effects of the drug acetaminophen and the industrial chemical mercuric chloride. The investigators will study the chemicals' impact on a wide range of biochemical, physiological and structural properties of the cells.