The Center for Alternatives to Animal Testing is an academic center affiliated with the Division of Toxicological Sciences in the Department of Environmental Health Sciences of the Johns Hopkins University Bloomberg School of Public Health.
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Research Grants 1986-1987
Synthesis and Secretion of Proteins by Isolated Mouse Hepatocytes as an Indicator of Cellular Injury
David J. Thomas, PhD
The Johns Hopkins School of Medicine, Baltimore, Maryland
Thomas has used Center funds to develop a mouse liver-cell culture and to study the effects of toxic substances on protein production by cells in this culture. He will improve the culture and develop more sensitive methods of measuring changes in protein production. This work should provide a new knowledge about the liver's response to injury and may lead to tests of liver toxicity and other kinds of toxicity.