The Center for Alternatives to Animal Testing is an academic center affiliated with the Division of Toxicological Sciences in the Department of Environmental Health Sciences of the Johns Hopkins University Bloomberg School of Public Health.
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Research Grants 1988-1989
Utilization of the Isolated Perfused Procine Skin Flap Preparation as an Alternative Animal Model for the Evaluation of Dermatoxicity
Nancy A. Monteiro, PhD
North Carolina State University's School of Veterinary Medicine, Raleigh, North Carolina
Monteiro is developing a method to evaluate the biochemical and morphological effects of toxic agents on skin. She is using a perfused porcine skin-flap preparation, previously worked up for percutaneous absorption studies, and will compare her results to those from a conventional dermal toxicity test.