The Center for Alternatives to Animal Testing is an academic center affiliated with the Division of Toxicological Sciences in the Department of Environmental Health Sciences of the Johns Hopkins University Bloomberg School of Public Health.

 

Johns Hopkins School of Public Health

Research Grants 1990-1991

Cholinergic Cell Lines as Models for Testing Drug Efficacy and Toxicity

J. Krystof Blusztajn, PhD
Boston University, Boston, Massachusetts

Blusztajn is assaying cultures of cholinergic neurons useful in studies of diseases such as Alzheimer's and Huntington's Chorea and in evaluating potential therapies. Using human neuroblastoma cells and mouse neuroblastoma/septal neuron hybrids, he'll evaluate enzymes, storage and substrate uptake typical of acetylcholine-producing neurons.