The Center for Alternatives to Animal Testing is an academic center affiliated with the Division of Toxicological Sciences in the Department of Environmental Health Sciences of the Johns Hopkins University Bloomberg School of Public Health.

 

Johns Hopkins School of Public Health

Development and Validation of a Skin Equivalent Suitable for the Evaluation of Dermal Toxicity & Percutaneous

Christopher Cullander, PhD
University of California, San Francisco, California

Cullander has developed a model of human skin using cultures of human keratinocytes. The model exhibits several similarities to human skin, useful for toxicity studies, yet a number of properties remain undetermined. Cullander plans to assess the model as a barrier to water diffusion. He also is altering the culture environment to promote growth of cells at the air-medium interface.