The Center for Alternatives to Animal Testing is an academic center affiliated with the Division of Toxicological Sciences in the Department of Environmental Health Sciences of the Johns Hopkins University Bloomberg School of Public Health.

 

Johns Hopkins School of Public Health

Research Grants 1990-1991

Toxic Responses in Cultured Human and Rat Nasal Epithelial Cells

Pamela Moore Mattes, PhD
University of Connecticut Health Center, Farmington, Connecticut

Tissues of the upper respiratory tract often respond to vaporized toxins by developing ulcers, inflammation or cell death. Mattes is culturing rat nasal cells as a potential human model for toxicity, evaluating biochemical and physiologic aspects of the response.