The Center for Alternatives to Animal Testing is an academic center affiliated with the Division of Toxicological Sciences in the Department of Environmental Health Sciences of the Johns Hopkins University Bloomberg School of Public Health.
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Research Grants 1990-1991
An In Vitro Models for Contact Allergy
Fredika Robertson, PhD
Robert Wood Johnson Medical School, Piscataway, New Jersey
Robertson will examine the ability of keratinocytes, epidermal cells with a suspected role in contact allergies, to release a variety of immune reaction by-products after exposure to cytokines or inflammatory agent TPA. Then she will compare that reaction with ones generated by known contact allergens. Such studies should clarify the role of keratinocytes and perhaps produce an in vitro model of contact allergy.