The Center for Alternatives to Animal Testing is an academic center affiliated with the Division of Toxicological Sciences in the Department of Environmental Health Sciences of the Johns Hopkins University Bloomberg School of Public Health.

 

Johns Hopkins School of Public Health

Research Grants 1990-1991

Molecular Characterization of Epidermal Cytokines -- A Potential In Vitro Assay for Contact Dermatitis

Daniel N. Sauder, MD
McMaster University, Hamilton, Ontario

The goal of Sauder's study is to develop a molecular assay for contact dermatitis based on generation of number of cytokines by keratinocytes and epidermal Langerhans cells. He will monitor production of cytokine mRNAs after addition of contact allergens and irritants to cultures of the epidermal cells.