The Center for Alternatives to Animal Testing is an academic center affiliated with the Division of Toxicological Sciences in the Department of Environmental Health Sciences of the Johns Hopkins University Bloomberg School of Public Health.
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Research Grants 1991-1992
Role of Lipid Peroxidation in UV-Enhanced Prostaglandin Synthesis
Alice P. Pentland
Washington University School of Medicine, St. Louis, Missouri
Ultraviolet (UV) light exposure is a common form of skin injury which manifests acutely as erythema and chronically as skin cancer and premature aging. Preliminary studies analyzed by Dr. Pentland's research group indicate that UV injury increases the sensitivity and the maximal response of the cell to multiple extracellular agonist. Dr. Pentland proposes to define and characterize the mechanism for UV injury in human tissue, specifically examining the role of lipid peroxidation in regeneration or degeneration of skin cells. This study may lead to an understanding of drugs which enhance or decrease peroxidation and therefore affect skin repair.