The Center for Alternatives to Animal Testing is an academic center affiliated with the Division of Toxicological Sciences in the Department of Environmental Health Sciences of the Johns Hopkins University Bloomberg School of Public Health.
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Research Grants 1991-1992
A Human In Vitro Skin Model for Toxicity Screening
Benjamin F. Trump, MD
University of Maryland, Baltimore, Maryland
Dr. Trump's goal is to develop and test an in vitro human skin model for toxicity screening. The project will employ the newest technologies in microscopy to make sure that the human kerotinocyte cell line (HaCAT) produces normal epidermal cell differentiation in skin irritancy testing. The approach will also define new endpoints for determining toxicity (e.g., monitoring intercellular calcium balances) which may replace other endpoints (cell growth, cell death and transformation). It will also test novel methods involving transmembrane signaling and gene expression that may predict later or chronic effects in humans, currently not possible by animal studies.