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Johns Hopkins Bloomberg School of Public HealthCAAT

Proceedings for TestSmart -- Endocrine Disruptors

  • WELCOME AND PRESENTATION OF THE GOALS OF CAAT'S TESTSMART -- ENDOCRINE DISRUPTORS
    Alan M. Goldberg, Johns Hopkins University
    James D. Yager, Johns Hopkins University

  • PERSPECTIVES ON THE ORIGIN OF THE ENDOCRINE DISRUPTION ISSUE AND FUTURE OPPORTUNITIES
    Theo Colborn, World Wildlife Fund

  • WHERE ARE WE TODAY? CURRENT UNDERSTANDING OF MECHANISMS OF ACTION OF ENDOCRINE DISRUPTORS
    John A. McLachlan, Tulane University Center for Bioenvironmental Research

  • OVERVIEW OF EDSTAC-PROPOSED TIER I SCREENING BATTERY
    Chair: Pamela J. Lein, Johns Hopkins University

  • OVERVIEW OF APPLYING EDSTAC-PROPOSED TIER SCREENING BATTERY
    Chair: Lynn R. Goldman, Johns Hopkins University

  • OTHER CONSIDERATIONS

    • Species/Strain Issues
      Robert M. Bigsby, Indiana University School of Medicine

    • An Alternative to the EDSTAC Screening Battery for Detecting Endocrine-Active Compounds
      John C. O'Conner, DuPont Haskell

  • QSAR

    • Structure-Activity Modeling of Xenoestrogens
      T. Wayne Schultz, University of Tennessee College of Veterinary Medicine

    • Risk Analysis Issues
      Paul A. Locke, Johns Hopkins University

  • RECEPTOR BINDING ASSAYS
    Chair: Barry R. Zirkin, Johns Hopkins University

    • The Use of Polarized Fluorescence to Assay Receptor/Ligand/ERE Binding
      William L. Alworth, Tulane University

    • Androgen Receptor Structure and Transcriptional Activity
      Elizabeth M. Wilson, University of North Carolina

    • Challenges of Confronting a Screening and Testing Program for Thyroid Disruptors
      R. Thomas Zoeller, University of Massachusetts

    • Cell Proliferation Assays
      Ana M. Soto, Tufts University School of Medicine

    • Aromatase as a Molecular Target of Natural and Synthetic Molecules
      Robert W. Brueggemeier, Ohio State University

  • OTHER METHODS IN DEVELOPMENT
    Chair: James D. Yager, Johns Hopkins University

    • Chemical Activated Luciferase Expression (CALUX®): Generation of High-Throughput Screens for Endocrine Disruptors
      George C. Clark, Xenobiotic Detection Systems, Inc.

    • The MCF-7 Focus Assay: In Vitro Screening for Estrogen Modulators Using a Physiologically Relevant Endpoint
      John F. Gierthy, New York State Department of Health University at Albany (SUNY), in collaboration with In Vitro Technologies, Inc.

    • Use of Noninvasive Imaging in Toxicology
      Karen L. Steinmetz, Xenogen Corporation