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Johns Hopkins Bloomberg School of Public HealthCAAT

CAAT Workshops

21st Century Validation Strategies for 21st Century Tools

VIDEO CLIPS (Quicktime format)

DAY 1

Introduction by Thomas Hartung, Director of CAAT
Plenary Speaker: Joanna Jaworska, Procter & Gamble-Europe: “ITS—Opportunities to better use existing data and guide future testing”

Panel: Rick Becker, American Chemistry Council
Jack Fowle, US Environmental Protection Agency
Joanna Jaworska, P&G Europe

Plenary Speakers: Kim Boekelheide, Brown University and
Melvin Andersen, The Hamner Institute for Health Sciences
“A mechanistic re-definition of adverse effects—a key step in the toxicity testing paradigm shift”

Panel: Raymond Tice, National Institute of Environmental Health Sciences
Jos Kleinjans, Maastricht University, The Netherlands
Rusty Thomas,The Hamner Institute for Health Sciences

DAY 2 

Plenary Speaker: Thomas Hartung, Johns Hopkins University
“Evidence-based toxicology—the toolbox of validation
for the 21st century?”

William Stokes, National Toxicology Program, Interagency Center for the Evaluation of Alternative Toxicological Methods
Anthony Cox, Cox Associates
Michael Holsapple, ILSI Health and Environmental Sciences Institute

Plenary Speaker: Daniel Dietrich, University of Konstanz
“Courage for simplification and imperfection in the 21st century assessment of endocrine disruption”

Chris Borgert, Applied Pharmacology & Toxicology, Inc.
Richard Judson, US Environmental Protection Agency
Catherine Willett, People for the Ethical Treatment of Animals and Closing Panel Discussion

Workshop Details

21st Century Validation Strategies for 21st Century Tools
July 13-14, 2010
Baltimore, MD

Chemical safety testing has come into the limelight. The emerging discussion of the TSCA reauthorization in the US and the start of REACH registration in the EU leave no doubt that a new approach to toxicology is required. That new approach was neatly outlined in the 2007 NRC report Toxicity Testing in the 21st Century: A Vision and a Strategy. Now it is time to put that vision into practice with a two-day forum on the new approach and its scientific challenges. The program will address the following topics: Integrated Testing Strategies, Modern Technology Integration, Evidence-based Toxicology, and Endocrine Disruption as a possible pilot area.

The Johns Hopkins Center for Alternatives to Animal Testing (CAAT) has teamed up with Doerenkamp-Zbinden Foundation, Society of Toxicology, American Chemistry Council, CropLife America, Society of Chemical Manufacturers and Affiliates, Soap and Detergent Association, American Petroleum Institute, Grocery Manufacturers Association, Consumer Specialty Products Association, Personal Care Product Council, Chemical Producers and Distributors Association, and Styrene Information and Research Center to offer a two-day forum on the new approach and its scientific challenges. The program will address the following topics: Integrated Testing Strategies, Modern Technology Integration, Evidence-based Toxicology, and Endocrine Disruption as a possible pilot area.

A half-day session will be devoted to each of these four pertinent aspects of the Tox-21c implementation. An opinion leader in each in field will present a keynote paper, to be followed by three renowned respondents and then an open one-hour discussion in the plenary.

The number of participants has been limited to allow intense discussions. The event will be documented for publication and webstreaming is planned.

Johns Hopkins Bloomberg School of Public Health,
615 N Wolfe St., Baltimore MD
July 13-14 2010
Sheldon Hall W1214

Tuesday. July 13
8:00-9:00           
Registration (Monument St. entrance—between Wolfe & Washington Sts)
Continental breakfast (Courtyard)

Session 1:  Integrated Testing Strategies (Sheldon Hall W1214)           
9:00-9:15           
introductory comments

9:15-10:15           
Plenary Speaker:   Joanna Jaworska, Procter & Gamble-Europe
“ITS—Opportunities to better use existing data and guide future testing”

10:15-10:45           
Refreshment Break (Courtyard)

10:45-11:45           
Panel: Rick Becker, American Chemistry Council
Jack Fowle, US Environmental Protection Agency
Troy Seidle, Humane Society International

11:45-12:45           
Discussion

12:45-1:30           
Lunch (Feinstone Hall E2030)

Session 2:  Enhancing Modern Technologies for Risk Assessment (Sheldon Hall W1214)
1:30-2:30           
Plenary Speakers: Kim Boekelheide, Brown University and
Melvin Andersen, The Hamner Institute for Health Sciences
“A mechanistic re-definition of adverse effects—a key step in the toxicity testing paradigm shift”

2:30-3:30           
Panel:
Raymond Tice, National Institute of Environmental Health Sciences
Jos Kleinjans, Maastricht University, The Netherlands
Rusty Thomas,The Hamner Institute for Health Sciences

3:30-3:45           
Break (Courtyard)

3:45-4:45           
Discussion

Wednesday. July 14
8:00                       
Continental breakfast (Courtyard)

Session 3:  Evidence Based Toxicology (Sheldon Hall W1214)
9:00-10:00           
Plenary Speaker: Thomas Hartung, Johns Hopkins University
“Evidence-based toxicology—the toolbox of validation
for the 21st century?”
           
10:00-10:30           
Refreshment Break

10:30-11:30           
Panel:
William Stokes, National Toxicology Program, Interagency Center for the Evaluation of Alternative Toxicological Methods
Anthony Cox, Cox Associates
Michael Holsapple, ILSI Health and Environmental Sciences Institute

11:30-12:30           
Discussion

12:30-1:15           
Lunch (Feinstone Hall E2030)

Session 4:  Endocrine Disruptors in Application (Sheldon Hall W1214)
1:15-2:15           
Plenary Speaker: Daniel Dietrich, University of Konstanz
“Courage for simplification and imperfection in the 21st century assessment of endocrine disruption”

2:15-3:15           
Panel
Chris Borgert, Applied Pharmacology & Toxicology, Inc.
Richard Judson, US Environmental Protection Agency
Catherine Willett, People for the Ethical Treatment of Animals

3:15-3:30
Refreshment Break (Courtyard)

3:30-4:30           
Discussion

4:30-5:00           
Concluding Remarks

Hotel recommendations:
 
The Admiral Fell Inn
888 S Broadway
866 583 4162 (reservations)
 
Inn at Henderson’s Wharf
1000 Fell St.
Phone:  (410) 522-7777

For more information, contact Marilyn Principe at mprincip@jhsph.edu

Validation slide

Thomas Hartung photo

Jaworska photo

Becker photo

panel photo