The Center for Alternatives to Animal Testing is an academic center affiliated with the Division of Toxicological Sciences in the Department of Environmental Health Sciences of the Johns Hopkins University Bloomberg School of Public Health.
TestSmart DNT
Monday, March 13
- Poster Sessions Welcome - Alan M. Goldberg, PhD
- Developmental Neurotoxicity Testing: The Challenge - Kevin Crofton PhD
- Developmental Neurobiology - David Ginty, PhD
- Summary of CAAT-CEFIC-ECVAM Workshop on DNT (April 2005): Incorporating In Vitro Alternative Methods for Developmental Neurotoxicity into International Hazard and Risk Assessment Strategies - Anna Price, PhD, and Sandra Coecke, PhD
- Policy Integration Issues
- Policy Integration - Paul Locke, JD, DrPH
- Government - Tina Levine, PhD
- Developmental Nerotoxicity Testing: Reducing Children's Risk of Learning and Develpmental Disabilities - Elise Miller, M.Ed.
- Animal Protection Concerns and Perspectives
- Developmental Neurotoxicity Guideline: Introduction and Perspectives - Jacques P. Maurissen, PhD
- DNT Testing in the Name of Children's Health: A Case for Precautionary Safety Factors - Troy Seidle, BSc
- The Science of Alternatives - DNT - Alan M. Goldberg, PhD
- Evaluation and Interpretation of Neurodevelopmental Endpoints for Human Health Risk Assessment - Julie Fitzpatrick , PhD
- Concurrent Sessions I
- A. Reduction and Refinement - What can be Done Now?
- Strategies to Reduce or Replace the Use of Animals in Endocrine Screening and Testing Studies - Leon Earl Gray Jr., PhD
- A Tier Approach to Screening for Developmental Neurotoxicants - Sidney Green, PhD, ATS
- Opportunities and Limitations in Applying Reduction and Refinement Strategies to DNT Testing - Robert D. Combes, PhD, FIBiol
- B. Approaches to Decision Making
- Information and Decision Making - Julia M. Gohlke, PhD
- ECVAM - Successes and Future Vision - Thomas Hartung, MD, PhD
- ICCVAM - Successes and Future Vision - Marilyn L. Wind , PhD
- C. From In Vitro Systems to Human Health Risk Assessment: Challenges and Possibilities
- Alternative Approaches to Validation: Modular Approaches - Leonard J. Sauers, PhD, DABT
- Validation for What Purpose? Regulatory Considerations and Needs - Abby A. Li, PhD
- A. Reduction and Refinement - What can be Done Now?
Tuesday, March 14
- Summary of Concurrent Sessions: Policy and ValidationReduction and Refinement Now - Susan Makris
- Approaches to Decision Making - Daniel S. Marsman, DVM, PhD
- Alternative Approaches to Validation - William S. Stokes, DVM
- OECD Test Guidelines Adoption Process - Patric Amcoff, PhD
- In Vitro Systems and Developmental Neurotoxicity - Evelyn Tiffany-Castiglioni, PhD
- Concurrent Sessions II
- A. Model Systems In Vitro
- Cell Lines / Primary Cultures
- In Vitro Models and Assays for Developmental Neurotoxicity Testing - Rae Nish, PhD
- Human Cord Blood-Derived Neural Stem Cell Line as a Model System for the Assessment of Developmental Neurotoxicity - Leonora Buzanska, PhD
- Brain Aggregate Cell Cultures (Brain Spheroid Cultures) - Paul Honegger, PhD
- B. Birds, Flies, and Others
- How did the Chicken Cross the TestSmart Road? - Susan Smith, PhD
- Sea Urchin Embryos as Biosensors for Teratogenesis by "Pre-Nervous" Neurotransmitter and Retinoic Acid Receptor Ligands - Jean M. Lauder, PhD
- Drosophila Models of Simple and Complex Disease and their Uses in Therapeutic Screening - Alice Schmid, PhD
- C. High Throughput Technologies and "Omics"
- Application of High Throughput Technology to Neurotoxicity Testing: What Can Be Assessed? - David Monteith, PhD
- How Can "Omic" Technologies Contribute to the Assessment of Developmental Neurotoxicity? - Jonathan Pevsner, PhD
- A. Model Systems In Vitro
- Development of Complementary Animal Models to the Classic Rodent Assays for Determining Neurotoxic Effects and Mechanisms During Development - Edward D. Levin, PhD
- Concurrent Sessions III
- A. Endpoints For DNT (in context of in vitro systems)
- Kinetic and Dynamic Characterization of Mouse Embryonic Neuronal Receptor Cells - Elaine Faustman, PhD, DABT
- Assessing Toxic Effects on Neuronal Morphogenesis - Pamela J. Lein, PhD
- Ideal Prerequisite for In Vitro Neurotoxicology - Karl Johe, PhD
- B. Fish
- High-Throughput Assessment of Small Molecule Bioactivity in the Zebrafish - Randall T. Peterson, PhD
- Zebrafish Model in Toxicology - Uwe Strähle, PhD
- C. Worms
- Development of a Medium-Throughput Toxicity Screen Using C. elegans - Jonathan H. Freedman, PhD
- C. elegans Neurobiology - Monica Driscoll, PhD
- A. Endpoints For DNT (in context of in vitro systems)
- Computational Toxicology — A Regulatory Perspective - Robert Kavlock, PhD
- Asia Pacific Perspectives on DNT
- DNT in Japan: Past, Present and Future - Ryozo Tsuji, DVM, PhD
Wednesday, March 15
- Summary of Concurrent Sessions: In Vitro Systems and Developmental Neurotoxicity
- Model Systems In Vitro - Michael Trush, PhD
- Endpoints for DNT (in context of in vitro systems) - Cynthia F. Bearer, MD, PhD
- High Throughput Technologies and "Omics" - William Mundy, PhD
- Summary of Concurrent Sessions: Alternative/Non-Mammalian Species and DNT
- Fish - Stephanie Padilla, PhD
- Worms - Kevin Crofton, PhD
- Birds, Flies, and Others - Holger Knaut, PhD
- Perspectives on DNT
- A Toxicologist Looks at DNT Costs and Benefits - David E. Ray, PhD
- A Pediatrician Looks at DNT - Cynthia F. Bearer, MD, PhD
- The Intersection of Developmental Neurobiology and Developmental Neurotoxicology:
- Opportunities in Translational Neuroscience - Pat Levitt, PhD