The Center for Alternatives to Animal Testing is an academic center affiliated with the Division of Toxicological Sciences in the Department of Environmental Health Sciences of the Johns Hopkins University Bloomberg School of Public Health.
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TestSmart--Endocrine Disruptors
February 21-22, 2001
Candler Building
111 Market Place, Suite 310
International Room
Baltimore, Maryland
Sponsors: 3M, Alberto-Culver Company, Bernice Barbour Foundation, Inc., Bristol-Myers Squibb Company, Exxon Mobil Corporation, The Gillette Company, Johnson & Johnson, Mary Kay Holding Corporation, Procter & Gamble Company, Rohm and Haas Company
Proceedings for TestSmart -- Endocrine Disruptors
- WELCOME AND PRESENTATION OF THE GOALS OF CAAT'S TESTSMART -- ENDOCRINE DISRUPTORS
Alan M. Goldberg, Johns Hopkins University
James D. Yager, Johns Hopkins University - PERSPECTIVES ON THE ORIGIN OF THE ENDOCRINE DISRUPTION ISSUE AND FUTURE OPPORTUNITIES
Theo Colborn, World Wildlife Fund - WHERE ARE WE TODAY? CURRENT UNDERSTANDING OF MECHANISMS OF ACTION OF ENDOCRINE DISRUPTORS
John A. McLachlan, Tulane University Center for Bioenvironmental Research - OVERVIEW OF EDSTAC-PROPOSED TIER I SCREENING BATTERY
Chair: Pamela J. Lein, Johns Hopkins University- Core principles guiding development of screening battery
Lynn R. Goldman, Johns Hopkins University - Endocrine Disruptors - An EPA Perspective
Steven K. Galson, Environmental Protection Agency - Validation Efforts - Endocrine Disruptor Screening Program
Anthony Maciorowski, Environmental Protection Agency - Current Status of Efforts to Validate the EDSTAC Tier 1 Screening Tests
Errol Zeiger, Consultant
- Core principles guiding development of screening battery
- OVERVIEW OF APPLYING EDSTAC-PROPOSED TIER SCREENING BATTERY
Chair: Lynn R. Goldman, Johns Hopkins University- Industry's Perspective
Richard A. Becker, American Chemistry Council - Endocrine Disruption: An Animal Protection Perspective
Martin J. Stephens, Humane Society of the United States
- Industry's Perspective
- OTHER CONSIDERATIONS
- Species/Strain Issues
Robert M. Bigsby, Indiana University School of Medicine - An Alternative to the EDSTAC Screening Battery for Detecting Endocrine-Active Compounds
John C. O'Conner, DuPont Haskell
- Species/Strain Issues
- QSAR
- Structure-Activity Modeling of Xenoestrogens
T. Wayne Schultz, University of Tennessee College of Veterinary Medicine - Risk Analysis Issues
Paul A. Locke, Johns Hopkins University
- Structure-Activity Modeling of Xenoestrogens
- RECEPTOR BINDING ASSAYS
Chair: Barry R. Zirkin, Johns Hopkins University- The Use of Polarized Fluorescence to Assay Receptor/Ligand/ERE Binding
William L. Alworth, Tulane University - Androgen Receptor Structure and Transcriptional Activity
Elizabeth M. Wilson, University of North Carolina - Challenges of Confronting a Screening and Testing Program for Thyroid Disruptors
R. Thomas Zoeller, University of Massachusetts - Cell Proliferation Assays
Ana M. Soto, Tufts University School of Medicine - Aromatase as a Molecular Target of Natural and Synthetic Molecules
Robert W. Brueggemeier, Ohio State University
- The Use of Polarized Fluorescence to Assay Receptor/Ligand/ERE Binding
- OTHER METHODS IN DEVELOPMENT
Chair: James D. Yager, Johns Hopkins University- Chemical Activated Luciferase Expression (CALUX®): Generation of High-Throughput Screens for Endocrine Disruptors
George C. Clark, Xenobiotic Detection Systems, Inc. - The MCF-7 Focus Assay: In Vitro Screening for Estrogen Modulators Using a Physiologically Relevant Endpoint
John F. Gierthy, New York State Department of Health University at Albany (SUNY), in collaboration with In Vitro Technologies, Inc. - Use of Noninvasive Imaging in Toxicology
Karen L. Steinmetz, Xenogen Corporation
- Chemical Activated Luciferase Expression (CALUX®): Generation of High-Throughput Screens for Endocrine Disruptors