The Center for Alternatives to Animal Testing is an academic center affiliated with the Division of Toxicological Sciences in the Department of Environmental Health Sciences of the Johns Hopkins University Bloomberg School of Public Health.
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TestSmart HPV
April 26-27, 1999
Hyatt Fair Lakes
12777 Fair Lakes Circle
Fairfax, VA 22033
A workshop of The Johns Hopkins Center for Alternatives to Animal Testing
TestSmart is a program of the Vision 20/20 forum
This workshop is partially funded through a grant by the Vira I. Heinz Endowment
Abstract for TestSmart--A Humane and Efficient Approach to Screening Information Data Sets (SIDS) Data
The HPV Challenge Program: Background and Perspectives
Karen Florini
Environmental Defense Fund
Why Worry About Ignorance?
- Absent data, no way to begin to assess risk
- Equally, no way to begin to assure safety
Or, to Pick Safer Substitutes
Toxic Substances Control Act 76
"It is the policy of the United States that... adequate data should be developed with respect to the effect of chemical substances and mixtures on health and the environment and that the development of such data should be the responsibility of those who manufacture [such] chemicals."
Assessing Data Availability
- National Academy of Sciences/National Research Council, Toxicity Testing (1984).
- 78% of high-volume chemicals lacked even minimal toxicity information
13 Years Later
- Environmental Defense Fund
Toxic Ignorance: The Continuing Absence of Basic Health Testing for Top-Selling Chemicals in the United States (July 1997).- EDF: Nongovernmental advocacy group, est. 1967, 300,000+ members
Toxic Ignorance Methodology
- Pilot study: review of publicly available data for sample of 100 regulated high-volume chemicals (>1 million pounds/year)
- Compared to minimum data set defined by OECD "Screening Information Data Set" (SIDS) project
- International consensus program, est. 90
- EDF: Human health data only (6 elements)