The Center for Alternatives to Animal Testing is an academic center affiliated with the Division of Toxicological Sciences in the Department of Environmental Health Sciences of the Johns Hopkins University Bloomberg School of Public Health.

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TestSmart HPV

April 26-27, 1999
Hyatt Fair Lakes
12777 Fair Lakes Circle
Fairfax, VA 22033

A workshop of The Johns Hopkins Center for Alternatives to Animal Testing
TestSmart is a program of the Vision 20/20 forum
This workshop is partially funded through a grant by the Vira I. Heinz Endowment

Abstract for TestSmart--A Humane and Efficient Approach to Screening Information Data Sets (SIDS) Data

Current Approaches & Potential Directions for Gathering SIDS Ecotoxicity Data

Phil Sayre
Environmental Protection Agency

Progress to Date

Reducing the number of chemicals going into testing
- No retesting of chemicals with adequate data
- Testing of categories of chemicals
- Guidance on use of SAR
- See http://www.epa.gov/chemrtk/guidocs.htm
Refinement, Reduction, and Replacement of animal testing
- Mammalian testing
- Fish acute toxicity testing: Reduction from 10 to 7 fish/concentration

Future Directions

Mammalian testing: See EPA 1999 Proposal to OECD which could result in 70% savings of animals per chemical http://www.epa.gov/chemrtk/humnanml.htm
Ecotoxicity testing: Replacement of fish acute testing?

Evolution Process for New Testing Methods (ICCVAM)

New Toxicological Methods: ICCVAM/Agency Review Process¹

¹Adapted from: Validation and Regulatory Acceptance of Toxicological Test Methods: A Report of the ad hoc Interagency Coordinating Committee on the Validation of Alternative Methods; NIH Pub. No. 97-3981, 1997, NIEHS, RTP, NC.