The 3Rs Hall of Honor aims to honor, recognize, and celebrate significant lifetime achievements in the pursuit of animal research and testing reduction, refinement, and replacement – principles collectively know as the 3Rs – by distinguished leaders in the field. Nominations are now closed for the 2025 cohort. Nominations will reopen Spring of 2026.

William Russell and Rex Burch originated the concepts of replacement, reduction, and refinement, which they published in their 1959 book, The Principles of Humane Experimental Technique. Russell and Burch proposed a new applied science, the aim of which was to improve the treatment of research animals while advancing the quality of scientific and medical research and testing. The full text of The Principles of Humane Experimental Technique can be found here: https://caat.jhsph.edu/russell-and-burchs-principles-of-humane-experimental-techniques/

Franz P. Gruber, a visionary in the 3Rs landscape, transitioned from a veterinary career to championing alternatives to animal experimentation in academia. As the transformative Editor-in-Chief of ALTEX, he elevated the publication to international prominence. His leadership as president of the Doerenkamp-Zbinden foundation led to the creation of endowed academic chairs worldwide, embedding the 3Rs into academic discourse. Franz, with his humility and inspirational spirit, significantly impacted the careers of countless researchers.

Martin L. Stephens, as a Senior Research Associate at CAAT and the Founding Director of EBTC, made indelible marks on the advancement of animal alternatives. His extensive service with the Humane World for Animals (formerly the Humane Society of the United States) and his role in reuniting Russell and Burch underscored the enduring influence of their seminal work, fostering a rejuvenated engagement with the 3Rs principles. Martin is remembered for his gentle demeanor and steadfast commitment to ethical scientific practices.

The full article introducing the 3Rs Hall of Honor and our inaugural inductees is available here: https://www.altex.org/index.php/altex/article/view/2795

Hall of Honor Committee

Rodger Curren, CEO, Institute for In Vitro Sciences (IIVS)

Dr. Curren received his B.S. from Purdue University, an M.S. from Ohio University, and a Ph.D. from Rutgers University. He co-founded the non-profit Institute for In Vitro Sciences (IIVS) in 1997. IIVS has provided educational and laboratory-based resources to organizations around the world. Dr. Curren has served on many committees and science advisory boards, including the Science Advisory Committee for the European Center for the Validation of Alternative Methods, and the Scientific Advisory Board for ICCVAM and NICEATM. Dr. Curren has earned multiple honors, including the Russell and Burch Award, the Bjorn Ekwall Memorial award, the FRAME annual lectureship, and the William and Eleanor Cave award.

Suzanne Fitzpatrick, Senior Science Advisor for Toxicology, FDA

Suzanne Fitzpatrick, Ph.D. is a Senior Science Advisor for Toxicology in FDA’s Center for Food Safety and Applied Nutrition.  A board-certified toxicologist in the U.S. and in Europe, Dr. Fitzpatrick is the FDA lead for the federal collaboration among FDA, EPA, and NIH, Toxicology Testing in the 21st Century (Tox 21), which looks to develop alternatives to animal testing as well as chair of the FDA Predictive Toxicology Roadmap Committee. Dr. Fitzpatrick played a pivotal role in helping launch the organs-on-a-chip tool, a revolutionary testing technology being evaluated by FDA.  She is also an Adjunct Professor at Johns Hopkins University, the FDA representative to the Johns Hopkins Center for Alternatives to Animal Testing Board, and past president of the American College of Toxicology and of the Nation’s Capital Chapter of the Society of Toxicology.  Dr. Fitzpatrick received her B.A. from the University of California at San Diego and her Ph.D. from Georgetown University.

John R. “Jack” Fowle III, Principal of Science, Inform, LLC

Dr. John R. “Jack” Fowle III received his baccalaureate and doctoral degrees in genetics from George Washington University. He is a board-certified toxicologist. He served in a variety of positions at the U.S. Environmental Protection Agency (EPA), most recently as Deputy Director of the Health Effects Division in the Office of Pesticide Programs (OPP). Since retiring from the EPA, he serves on the Board of Directors for the Institute of In Vitro Sciences, is Past President of the Board of Trustees for the Evidence Based Toxicology Collaboration (EBTC) and is a member of the Advisory Board for the Johns Hopkins Center for Alternative Animal Testing (CAAT), both at Johns Hopkins. He is a Fellow of the Society for Risk Analysis and the recipient of the Society’s 2022 Distinguished Achievement Award.

Daniel Krewski, Professor Emeritus, University of Ottowa

Dr. Krewski currently serves as Professor Emeritus in the School of Epidemiology and Public Health in the Faculty of Medicine at the University of Ottawa.  From 2001–2023, he was Scientific Director of the McLaughlin Centre for Population Health Risk Assessment at uOttawa.  Previously, he held a number of senior positions in Health Canada, including Director, Risk Management in the former Health Protection Branch.  Dr. Krewski has served on a number of national and international committees focusing on advancing public health, including chairing the National Academy of Sciences committee that published the influential report on Toxicity Testing in the 21st Century in 2007.

Jacob Larson, Senior Research Scientist, Herbalife

Jacob Larson has been working in toxicology for over 20 years. He received his Masters degree in toxicology from University of Michigan and is certified by the American Board of Toxicology. He currently works as a Senior Research Scientist for Herbalife. In addition to CAAT, he is a member of the Society of Toxicology and is on the steering committee for the Botanical Safety Consortium.

Sue Leary, President and CEO, Alternatives Research & Development Foundation (ARDF)

Sue A. Leary has a B.S. in Biology and M.S. in Nonprofit Management. Her career has focused on coordination of programs and services; education and advocacy; administration and planning; and membership development in nonprofit organizations. From 1995 – 2025, she also served as President of ARDF’s affiliate, American Anti-Vivisection Society (AAVS). She has served on a number of boards, including the Advisory Board of CAAT. From 2020 – 2024, she was a member of the Scientific Advisory Committee on Alternative Toxicological Methods regarding activities of the Interagency Coordinating Committee for the Validation of Alternative Methods.

Vasiliki Machairaki, Associate Professor, Department of Genetic Medicine, Johns Hopkins University School of Medicine

Dr. Vasiliki Machairaki is an Associate Professor in the Department of Genetic Medicine at the Johns Hopkins University School of Medicine. She earned her Ph.D. in Molecular Biology from the University of Crete and the Institute of Molecular Biology and Biotechnology (IMBB), followed by postdoctoral training in neurodegenerative disease modeling at Johns Hopkins University. Her research centers on human induced pluripotent stem cell (iPSC) technologies and 3D brain organoid systems to investigate the cellular and molecular mechanisms underlying neurodegenerative diseases, with a particular focus on Alzheimer’s disease (AD). In addition to her research, Dr. Machairaki is a member of the Johns Hopkins Precision Medicine Center of Excellence in Alzheimer’s Disease, where she contributes to the development of personalized stem cell models for defining molecular subtypes of AD.

Kathryn Page, Product Safety Toxicologist, The Clorox Company

Kathryn Page is a highly experienced toxicologist specializing in product safety and global stewardship, currently serving as a Principal Scientist at The Clorox Company since January 2015. Previous roles at The Clorox Company include Senior Scientist and Scientist II, focusing on toxicological assessments. Prior to this, Kathryn held a PostDoc position at UC Berkeley, where responsibilities included leading a multi-institutional NIH grant related to iron metabolism and conducting extensive laboratory management tasks. Kathryn’s academic background includes a PhD in Adaptive Biosciences from The University of Manchester and a BSc Hons in Genetics from Newcastle University. Additional research experience includes investigating aluminum toxicity and metal homeostasis in Caenorhabditis elegans at the Buck Institute for Age Research.

Bernard Robaire, Professor, McGill University

Bernard Robaire obtained his B.A from UCLA and his Ph.D. from McGill University. After a postdoctoral fellowship at Johns Hopkins University, he returned to McGill to take up a joint appointment in the Departments of Pharmacology & Therapeutics and of Obstetrics & Gynaecology where he is currently Distinguished James McGill Professor.  Dr. Robaire’s research interests focus on effects of endocrine disruptors on the reproductive system, aging of the male reproductive system, male-mediated reproductive toxicology, and the structure, function, and regulation of the epididymis. This research activity has resulted in over 250 journal articles, 70 book chapters, and editing/co-editing of 10 books. He conceived and is Editor of the Handbook of Andrology.

Andrew Rowan, President, WellBeing International

Andrew Rowan (DPhil) has spent 48 years of animal welfare science & environmental advocacy. He served on government/corporate consultative committees & on national & international NGO Boards. He was the CEO of Humane Society International (1998-2017) & Board Chair of the Humane Society Wildlife Land Trust. He was a Professor at Tufts Cummings School of Veterinary Medicine where he set up the Tufts Center for Animals and Public Policy (1983), launched a journal on human-animal relations (Anthrozoos, 1987-97), launched the first Masters’ degree on animals & public policy (1995), & Chaired the Department of Environmental Sciences (1993-97). He has authored or edited several books & over one hundred academic papers on animal research & alternatives, on companion animal demographics & management, on wildlife management, & on human-animal interactions. He was a Rhodes Scholar (1968-1971).

Nikaeta Sadekar, Respiratory Toxicologist, Research Institute for Fragrance Materials, Inc. (RIFM)

Dr. Nikaeta Sadekar serves as Principal Scientist at the Research Institute for Fragrance Materials (RIFM), where she leads the Local Respiratory Toxicity Safety Assessment endpoint and directs its research program. Her work involves extensive collaboration with academic institutions, governmental agencies, and industry stakeholders to develop and advance the science of respiratory safety. Dr. Sadekar’s expertise includes the management of research programs focused on the development of respiratory New Approach Methodologies (NAMs) and the conduct of human health risk assessments. She is also actively engaged in the communication of scientific findings to diverse audiences.

Sonja von Aulock, Editor-in-Chief, ALTEX – Alternatives to Animal Experiments

Sonja von Aulock is editor-in-chief of the scientific journal ALTEX – Alternatives to Animal Experiments (www.altex.org) and its sister journal ALTEX Proceedings (https://proceedings.altex.org/) since 2011 as well as CEO of the Swiss not-for-profit society ALTEX Edition, which publishes both journals, since 2018. She studied biology at the University of Konstanz, obtained her PhD in biochemical pharmacology, and led a junior research group on microbial profiling before joining ALTEX Edition. She is on the board of Center for Alternatives to Animal Testing (CAAT) and (CAAT)-Europe.

Camila Sgrignoli Januario, Senior Program Manager, Johns Hopkins Center for Alternatives to Animal Testing (CAAT)

Camila Sgrignoli Januario, has a B.A in Political Science and a master’s in Public Administration. Her work focus on strategic planning, program development, and cross-cultural collaboration, developing socio and educational programs, managing boards, and organizing major events such as the MPS World Summits and the Exposome Moonshot Forum.

Danilo Tagle, Director, NCATS/NIH

Member Emeritus

Danilo Tagle is the former Director, Office of Special Initiatives at the National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH) where he led efforts in developing innovative tools and technologies that can greatly accelerate development of diagnostics and therapeutics. He currently serves on the Biological and Physical Sciences Federal Advisory Committee, the White House OSTP Microgravity Science and Technology Interagency Working Group, and serves as the point-of-contact for the liaison to the NASA/NIH/Department of Health and Human Services partnership. Dan obtained his PhD and MS in molecular biology and genetics from Wayne State University School of Medicine. He was an NIH National Research Service Award postdoctoral fellow in human genetics at the University of Michigan. Dan has authored many scientific publications and has garnered numerous awards.

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