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3Rs Training Webinar series 2021

Out of the seven 3Rs Training webinars we organized this year, four are in English and three are in German – one being a talk by CAAT Director Thomas Hartung. They are now available on YouTube. They include a talk on Human-relevant Airways Models for Disease Research by Lindsay Marshall, PhD, HSUS/HSI/Biomed21; a talk about Norecopa: a National Consensus Platform working to advance the 3Rs internationally by Prof. Adrian Smith, Norecopa; Talk by Laure-Alix Clerbaux, PhD, Joint Research Centre of the European Commission about Depicting the pathogenesis of COVID-19 using the Adverse Outcome Pathway; and a talk about The Principles of the 3Rs: Lessons Learned from History by Anne van Veen, PhD, Radboud University, Nijmegen, The Netherlands. We will continue our 3Rs Training series in February with another talk in English. Details will be announced via the CAAT Newsletter.

CAAT’s 40th Anniversary Celebration

Opening remarks – Andrew Rowan and Alan Goldberg

Developmental NeuroToxicity (DNT) – Helena Hogberg and Tim Shafer

Evidence-based Toxicology Collaboration (EBTC) – Sebastian Hoffmann and Daniele Wikoff

Good Cell Culture Practice (GCCP) Program – Marcel Leist and Sandra Coecke

Green Toxicology – Nick Anastas and Alexandra Maertens

Cosmetic and TestSmart Program – Tony Gaspari and Julia Fentem

Education program – Deborah Rudacille and Lena Smirnova

Refinement Program – Joanne Zurlo and Kathrin Herrmann

World Congress on Alternatives – Bert van Zutphen

Policy Program – Paul Locke and Pamela Frasch

Future Perspectives – Thomas Hartung

Challenges and Opportunities for Overcoming Dog Use in Agro-chemical Evaluation and Registration

The 90-day dog study is being conducted for agro-chemical authorization when it is not always needed to adequately address hazard identification and human safety and risk. This virtual workshop will host a series of presentations on the role the dog study has played in regulation of agro-chemicals in both the U.S. and Europe during the past 20 years and what approaches may be employed to substantially reduce its use. The public will have the opportunity to submit comments and questions to be discussed during the following invitation-only workshop.
Presentations:
• Title: The value of the 90-day dog study in pesticide registration toxicity testing in the U.S.
Authors: Patricia L. Bishop (The Humane Society of the United States), Douglas C. Wolf (Syngenta Crop Protection), and Vicki Dellarco (Independent Consultant)
• Title: Incorporating toxicokinetic and toxicity data to evaluate the value added from using dogs in subchronic toxicity testing for agrochemicals
Authors: Lynea Murphy (Corteva AgriScience), Robert Mingoia (Corteva AgriScience), Jean Domoradzki (Corteva AgriScience) Claire Terry (Corteva AgriScience)
 • Title: Relevance of dog studies for the derivation of health-based guidance values for Plant Protection Products Approval - EFSA
Authors:  Martina Panzarea (EFSA) and Andrea Terron (EFSA)
• Title: Species Liver-Chip to assess cross-species drug toxicity and human relevance.
Author: Kyung-Jin Jang (Emulate)

Alternative approaches in Developmental Neurotoxicity - a farewell symposium for CAAT’s deputy director Helena Hogberg

There is a paucity of information concerning the developmental neurotoxicity (DNT) hazard posed by industrial and environmental chemicals, drugs and consumer products. New testing approaches will most likely be based on batteries of alternative and complementary (non-animal) tests.

This symposium has the objective to discuss and present the status of DNT and honor Helena Hogberg for her 12 years working at the Center for Alternatives to Animal Testing and moving further to NICEATM at NIEHS.

Helena Hogberg – Open remarks

Alan Goldberg and Pamela Lein – DNT—How it all began

Lena Smirnova – DNT journey of CAAT research

Ellen Fritsche – Scientific validation of the neurosphere DNT test methods

Iris Mangas - The DNT programme in EFSA, past, present and future.

Tim Shafer - DNT NAMs are already being used

Magda Sachana - OECD DNT project: seeing the light at the end of the tunnel

Anna Price – Future of DNT testing: evaluation of effects induced by mixtures using NAMs

Mamta Behl - Beyond DNT-  A great colleague and a wonderful friend

Thomas Hartung – Director remarks

Helena Hogberg – Closing remarks

Toxicological research is often conducted according to highly uneven standards. Difficulties in comparing the methods used by individual studies often seriously limits our ability to draw firm conclusions from even quite large bodies of evidence.

EBTC's December symposium was about new developments in solving this problem, in particular the marrying of novel techniques in semantic technology to traditional but challenging assay ring-testing and development.

 

There will be presentations and a Q&A panel from three highly experienced researchers in this space.

 

Dr Anne Thessen (University of Colorado Anschutz) will introduce some of the more surprising issues around assay consistency, including recent research that suggests scientists cannot reliably distinguish between live and dead zebrafish embryos. She will then describe how semantic technology can help improve this situation - not only in terms of data interoperability, but in reliably performing tasks such as scoring images of larvae.

 

Dr Sebastian Hoffmann (EBTC) will present an overview of EBTC's recent systematic review of zebrafish embryotoxicity assays. He will show why standardization is becoming such an important issue, particularly in an age where studies are viewed collectively and evidence synthesis is increasingly central to toxicology and chemical risk assessment.

 

Dr Kristen Ryan (National Toxicology Program) will discuss how broader uptake of the use of zebrafish in toxicology screening is hampered by lack of harmonization in experimental protocols, data analysis, and reporting of research. The SEAZIT program has been launched to address this; Dr Ryan will present on the goals of the program and how it will achieve them.

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