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Johns Hopkins Bloomberg School of Public HealthCAAT
 

10th Annual 3Rs Symposium: The 3Rs in Action!

10th Annual 3Rs


ONLINE EVENT

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Wednesday & Thursday, May 17-18, 2023 | 8:30 AM to 5:00 PM EST

This event will be submitted for RACE Credits.

This symposium will focus on reduction, refinement, and replacement methods to improve laboratory animal welfare while maintaining or improving scientific results. It is jointly organized by the Center for Alternatives to Animal Testing, Johns Hopkins University Bloomberg School of Public Health, the Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, the USDA’s Animal Welfare Information Center (AWIC) at the National Agricultural Library, and the Office of Laboratory Animal Welfare, National Institutes of Health.

Sessions are designed for investigators, laboratory animal veterinarians, care staff, and IACUC members and staff. Residents, students, and postdocs are also welcome!

Please join us online as we learn from the speakers and each other! There will be opportunities built into the program for attendees to ask questions, comment, or offer suggestions. We look forward to seeing you there!

NOTE: If you need sign language interpretation please let us know.

Link to online access will be sent 24 hours before the event.

Agenda:

Day 1: Session 1: Barriers to refinement

  • 8:30 - 9:00 AM ET | Organizers’ Welcome: 10th Anniversary with Pat Brown, Eric Hutchinson, Joanne Zurlo, Kathrin Herrmann, and Kristina Adams
  • 9:00 - 9:45 AM ET | Keynote: "Orphan" 3Rs | Thomas Hartung, MD, PhD (Johns Hopkins University, USA)
  • 9:45 - 10:30 AM ET | Refinement and replacement options for non-human primates | Hannah Buchanan-Smith, PhD (University of Stirling, UK) and Jarrod Bailey, PhD (Animal Free Research, UK)
  • 10:30 - 10:45 AM ET | Break
  • 10:45 - 11: 30 AM ET | How Do We Effectuate the 3Rs? | Merel Ritskes-Hoitinga, DVM, PhD (Utrecht University, The Netherlands)
  • 11:30 AM - 12:30 PM ET | Interactive guided discussion: Why do we adopt some 3Rs but not others? | Thomas Hartung, Merel Ritskes-Hoitinga, Melanie Graham, and Jarrod Bailey

12:30 - 1:15 PM ET | Lunch Break

Day 1: Session 2: The right R for the right study

  • 1:15 - 2:00 PM | The Impact of Behavioral Management on the Primate Experience, Their Caregivers, and Successful Clinical Translation | Melanie Graham, MPH, PhD (University of Minnesota, USA)
  • 2:00 - 2:45 PM ET | Performance Assessment of a Liver-Chip for Prediction of Drug-Induced Liver Injury and Incorporation Within Laboratory Workflows | Lorna Ewart, CSO (Emulate, USA)
  • 2:45 - 3:00 PM ET | Break
  • 3:00 - 3:45 PM ET | Replacing Sentinel Rodents With Environmental Health Monitoring: Evidence & Practical Implementation | Megan LaFollette, MS, PhD (The 3Rs Collaborative, USA)
  • 3:45 - 4:45 PM ET | Strategies To Implement the 3Rs: Refined Handling | Liz Nunamaker, PhD, DVM, DACLAM, DACAW (Global Animal Welfare & Training, Charles River Laboratories, USA)

Day 2: 3Rs Implementation

  • 8:30 - 9:15 AM ET | Practical Implementation of Enrichment for Laboratory Zebrafish | Chloe Stevens, PhD (RSPCA, UK)
  • 9:15 - 10:00 AM ET | Refinements in Cage Bedding for the Improvement of Mouse Welfare and Husbandry Efficiency | Brooke Pallas, DVM (University of Michigan, USA)
  • 10:00 - 10:15 AM ET | Break
  • 10:15 - 11: 00 AM ET | Does Enrichment Affect Data Replicability? Results of a Meta-analysis and Implications for Translation | Georgia Mason, PhD (University of Guelph, Canada)
  • 11:00 - 11:45 AM ET | Practical Application of Cumulative Endpoints | Pat Turner (Charles River Laboratories, USA)

11:45 AM - 12:45 PM ET | Lunch Break

  • 12:45 - 1:30 PM | Pathways to continuous improvement | Steve Niemi, DVM, DACLAM (Boston University, USA)
  • 1:30 - 3:00 PM ET | Panel discussion with AAALAC/FDA/NIH/USDA on the 3Rs
    • Gary Borkowski, DVM, MS, DACLAM (AAALAC International, USA)
    • Gwen Maginnis, DVM (USDA-APHIS, Animal Care, USA)
    • Suzanne Fitpatrick, PhD, DABT (FDA, USA)
    • Nicolette Petervary, VMD, MS, DACAW (Director, Division of Policy and Education, Office of Laboratory Animal Welfare (OLAW), National Institutes of Health, USA)
  • 3:00 - 3:15 PM ET | Break
  • 3:15 - 4:15 PM ET | Breakout Session
  • 4:15 - 4:30 PM ET | Wrap-up of Symposium