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Johns Hopkins Bloomberg School of Public HealthCAAT

CAAT Information Day: New Approaches to Assessing Countermeasures to Bioterrorism Agents

Tuesday, May 22, 2012
10:00 am – 4:00 pm
Sheldon Hall (W1214)
Johns Hopkins Bloomberg School of Public Health
615 North Wolfe Street, Baltimore, MD

Late in 2011, the National Research Council published a report on Animal Models for Assessing Countermeasures to Bioterrorism Agents. The report summarized the status of current animal models to assess the efficacy of medical countermeasures, pointing out the imperfection of the existing models and the need for human clinical data to help inform the process. In addition, the committee that authored the report recommended that the Department of Defense examine scientific gaps in information needed to utilize alternative methods, identify areas in which current in vitro and in silico methods could be utilized as adjunct methods to animal models to help improve their usefulness and develop criteria for developing technologies to ultimately replace animal use for these purposes.

The committee also recommended changes in the standard practice of using animal models to more accurately represent a clinical course of treatment in humans. This may be done by developing a matrix to compartmentalize data from components of specific animal studies that best reflect the human situation.

The Johns Hopkins Center for Alternatives to Animal Testing is organizing an information day to examine the state of the art of new technologies to replace animal use as well as those that will modify current animal protocols to increase their efficiency and improve animal welfare.

Program (as of 5/17/2012)

10:00: Welcome
Thomas Hartung (Johns Hopkins-CAAT)

10:15: Summary and recommendations of the NRC report
George Korch (Johns Hopkins Bloomberg School of Public Health and HHS Assistant Secretary for Preparedness Response) (Co-chair of NRC committee)

10:40: Animal models and beyond in regulatory science
Lisa Hensley (US Food and Drug Administration)

11:05: Getting to the animal rule
Judy Hewitt (National Institute of Allergy and Infectious Diseases- NIAID)

11:30: DTRA’s long-term goals and visions for medical countermeasures and alternatives to the use of animals
William C. (Clint) Florence (Defense Threat Reduction Agency - DTRA)

12:00: Lunch

12:45: Emerging infectious disease: influenza medical countermeasure program
David Gibson (US Army)

1:10: In vitro models of the human immune system for evaluating bioterrorism agent countermeasures
William Warren (Sanofi-Pasteur)

1:35: Fluidic-enhanced model of the human conducting airways
Sonia Grego (RTI International)

2:00: Efforts to find common signatures for vascular leakage from select agents
Marti Jett (US Army Center for Environmental Health Research)

2:30: Break

2:45: Organs-on-Chips as potential alternatives to animal models for safety and efficacy testing
Anthony Bahinski (Wyss Institute, Harvard University)

3:10: Systems biology of host-toxicant interactions
Jennifer Sekowski (US Army)

3:35: Lessons learned in validation of alternative methods: avoiding the snags
Thomas Hartung (Johns Hopkins-CAAT)

4:00: Discussion led by Harry Salem (US Army)

4:30: Adjourn

Registration Form



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($25 cancellation fee)

Complimentary Registration: Federal employees, Johns Hopkins Faculty/Students/Staff.


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Fax:  410-614- 2871


Mailing Address: CAAT
615 N Wolfe St, W7032
Baltimore MD 21205

For further registration and event information, contact Marilyn Principe at