Welcome to our comprehensive directory of global organizations devoted to the principles of the 3Rs – Replacement, Reduction, and Refinement – and the development of alternatives to animal testing. These centers, spanning continents from North America to Asia, tirelessly work to promote ethical research practices, educate the scientific community, and advance non-animal research methods.

Whether you’re a researcher seeking expert guidance, a student exploring humane science, or an animal welfare advocate interested in the latest developments, this collection of resources will connect you with leading organizations dedicated to this cause.

• 3R-Center Tübingen
• 3Rs Centre Utrecht
• The 3Rs Collaborative (USA)
• ANZCCART (Australian and New Zealand Council for the Care of Animals in Research and Teaching)
• APHIS (Animal and Plant Health Inspection Service) [USDA, USA]
• AFR (Animal-free Research)
• ARDF (Alternatives Research & Development Foundation) [USA]
• AWIC (Animal Welfare Information Center) [USA]
• CAAT (The Johns Hopkins Center for Alternatives to Animal Testing) [USA]
• CCAC’s Three R’s Microsite (Canadian Council on Animal Care)
• Centre for Advanced Research & Development on Alternative Methods (CARDAM)
• Centro de Alternativas al uso de Animales en la Enseñaza [Mexico]
• Danish 3R-Center
• EBTOX (Evidence-Based Toxicology (EBT) Collaboration)
• ECOPA (European Consensus-Platform for Alternatives)
• ECVAM (European Centre for the Validation of Alternative Methods)   
• Einstein Center 3R (Berlin)
• EPAA (European Partnership for Alternative Approaches to Animal Testing)
• Ethics of Medical Research with Animals (The Hastings Center) [USA]
• FC3R (3R French Center)
• FIN3R (3R Centre Finland)
• FRAME (Fund for the Replacement of Animals in Medical Experiments) [UK]
• FRANCOPA (French Platform for the Development of Alternative Methods in Animal Testing)
• GTEMA (Spanish Group on Alternative Methods)
• HSUS (Humane Society of the United States) [USA]
• I-CARE (International Centre for Alternatives in Research and Education) [India]
• ICCVAM/NICEATM (Interagency Coordinating Committee for the Validations of Alternative Methods / NICEATM (NTP Interagency Center for the Evaluation of Alternative Toxicological Methods) [USA]
• IFER (The International Foundation for Ethical Research) [USA]
• ILAR (Institute for Laboratory Animal Research) [USA]
• IIVS ( Institute for in vitro Science) [USA]
• The Institute for the 3Rs [Korea]
• JaCVAM (Japanese Center for the Validation of Alternative Methods)
• Korean Society of Alternatives to Animal Experiments
• MAWA (Medical Advances Without Animals)
• NC3Rs (National Centre for the Replacement, Refinement and Reduction of Animals in Research) [UK]
• NEAVS (New England Anti-Vivisection Society) [USA]
• Norecopa (Norwegian Consensus Platform on Alternatives) (Norwegian National Platform for Alternatives)
• Prince Laurent Foundation [Belgium]
• REMA (Spanish National Platform on Alternatives) [Spain]
• RSPCA (Royal Society for the Prevention of Cruelty to Animals) [UK]
• SCAW (Scientists Center for Animal Welfare) [USA]
• ZEBET (Centre for Documentation and Evaluation of Alternative Methods to Animal Experiments) [Germany]