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Alan and Helene Goldberg In Vitro Toxicology Grants

NEW: Fast Track Grant for Research on Non-Animal Approaches to Investigate Mechanisms, Medicines, and Vaccines for Coronaviruses: Currently Closed

Grantees

Christine Bear
Senior Scientist, Programme in Molecular Medicine
Hospital for Sick Children

Development of a platform for SARS-CoV-2 therapy testing and development using primary nasal epithelial cultures

Parastoo Khoshakhlagh
Co-founder, President and CEO, GC Therapeutics, Inc.
Alex NG, PhD
Co-PI, GC Therapeutics,Inc.

Investigating the effects of hypertension drugs on the Infectivity of SARS-CoV-2 in synthetically accelerated vascularized type II pneumocyte-containing pulmonary organoids

Information about our coronavirus grants, awardees, and finalists, may be found here


For Awards information, visit here

Alan Goldberg

The Johns Hopkins Center for Alternatives to Animal Testing (CAAT) is pleased to announce the establishment of the Alan and Helene Goldberg In Vitro Toxicology Grants program (formerly CAAT Grants Program). The program was renamed in 2019 to honor the Founding Director (Emeritus) of the center, Alan M. Goldberg, and his wife, Helene Goldberg (BSPH, MPH 1981). Alan is a professor of toxicology at the Bloomberg School of Public Health and was director of CAAT from its founding in 1981 until 2009. He then served as a Pew Commissioner on the study of the Impact of Industrial (US) Farm Animal Production on issues of public health, environment, animal welfare, and social justice, and was a coauthor of the Pew report Putting Meat on the Table: Industrial Farm Animal Production in America. He is currently principal of the Global Food Ethics Project at Johns Hopkins University, where he is developing a framework for ethical food systems. His new book, Feeding The World Well: A Framework for Ethical Food Systems, will be released this July from Johns Hopkins University Press.

The grants program (http://caat.jhsph.edu/programs/grants) is a centerpiece of our work, providing initial funding for scientists to develop alternatives to the use of animals in biomedical research and product safety testing. To date, the center has funded over 300 grants (including renewals) for a total of more than $6 million.

The Johns Hopkins Center for Alternatives to Animal Testing (CAAT) is soliciting projects that focus on the implementation of the NAS Report: Toxicity Testing in the 21st Century: A Vision and a Strategy in the following areas:

  • Proposals Relating to Toxicology: Maximum grant amount is $40,000. The objective should be to significantly reduce or replace laboratory animals. Examples of acceptable projects could include: providing mechanistic understanding of in vitro responses to toxicants in human cells, development of AOPs, or conducting systematic reviews. Consideration should be given to the translation of this new method to evaluate/predict health outcomes.
     
  • Proposal Relating to Refinement:  See Science-Based Refinement Awards – funded separately.

Although relatively small individually, these grants offer critical seed money that allows researchers to demonstrate the value of a particular area of study so they can gain support from the NIH and other sources.

We have a stringent, peer-reviewed process for selecting the recipients of these grants. This process consists of sending each application to at least four experts in the field from academic, industrial, and government institutions. These reviewers evaluate the applications with regard to scientific merit, budget appropriateness, suitability to CAAT's mission, and expertise of the investigators. They also assign a priority score based on the scoring system used by the NIH.

At the CAAT annual advisory board meeting, these applications are reviewed by board members. Board members constitute the voting contingent for the grant applications and assign priority scores in a secret ballot format based upon a synopsis of the outside reviews and the board reviewers. The applications are then ranked in order of priority score and those that receive fundable scores are awarded funds based upon availability of money for the fiscal year.

We continue to monitor the long-term progress of the Research Grant Program by requiring our grant recipients to submit copies of publications resulting from the work supported by CAAT grant funds. We maintain a list of publications and an archive of journal reprints.

We continue to monitor the long-term progress of the Research Grant Program by requiring our grant recipients to submit copies of publications resulting from the work supported by CAAT grant funds. We maintain a list of publications and an archive of journal reprints.

2021-2022 Grants: Call for Pre-proposals—Currently CLOSED

Please sign up for our CAATwalk email newsletter to be notified when the pre-proposals are announced

Pre-proposal Details (Will go live when grants are again opened)

Pre-proposal Form (Will go live when grants are again opened)

During an open period for call for proposals, please click the link below to be taken to the call for proposals and the online proposal submission.

For funding period 2020-21, CAAT granted three projects.

  • Samantha Hughes, HAN University of Applied Sciences (new)
    Resolving the Black Box: Using worms and TK/TD modeling to identify and characterize qAOP's
  • Jens Christian Schwamborn, OrganoTherapeutics SARL (new)
    Analysis of Parkinson's disease associated alpha-Synuclein aggregate toxicity in patient specific brain organdies
  • Emanuela Corsini, Universiti degli Studi di Milano (renewal)
    Understanding allergen potency: role of protein kinase C activation in the vigor of dendritic cell activation  

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Grants Program Coordinator: Helena Hogberg (hhogber2@jhu.edu)

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Previous Grants

2020-2021 Grants
2019-2020 Grants
2018-2019 Grants
2017-2018 Grants
2016-2017 Grants
2015-2016 Grants
2014-2015 Grants
2013-2014 Grants
2012-2013 Grants
2011-2012 Grants
2010-2011 Grants
2009-2010 Grants
2008-2009 Grants
2007-2008 Grants

Previous Grants Archive